From basic biological studies to generating novel disease models, SBI’s injection- and transfection-ready PrecisonX™ Cas9 SmartNuclease™ mRNA is here to move your in vivo genome engineering projects forward faster.Use with an appropriate gRNA and, if your application needs it, a homologous recombination (HR) targeting vector for gene knock-ins, knock-outs, editing, and tagging. The Cas9 SmartNuclease will generate a double-strand break (DSB) at the site specified by the gRNA, and this DSB can be efficiently and precisely repaired in a manner that includes your desired mutation through the use of an HR targeting vector.